The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
RAD51 recombinase polymerizes at the site Seasoning of double-strand breaks (DSBs) where it performs DSB repair.The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis.The polymerization of RAD51 is regulated by a number of RAD51 mediators, such as BRCA1, BRCA2, RAD52, SFR1, SWS1, and the five RAD51 paralogs, including XRCC3.We